Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) can affect multiple organs in addition to the skin.

Extracutaneous manifestations may include:

(1) ocular involvement (conjunctivitis, dry eye, corneal erosions, etc)

(2) oral mucositis

(3) mucositis of the gastrointestinal tract

(4) pulmonary involvement (bronchiolitis obliterans, chronic bronchitis, interstitial lung disease)

(5) hepatitis

(6) chronic kidney disease (CKD)

(7) genitourinary mucosa (vulvovagnitis, other)


If the patient has extracutaneous findings but no rash then the diagnosis of atypical SJS may be made.

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