Scleromyxedema is a systemic disorder with extracutaneous manifestations and a number of complications.
Extracutaneous manifestations:
(1) dermatoneuro syndrome
(2) arthralgias or arthritis
(3) neuropathy and/or carpal tunnel syndrome
(4) cardiac disease (mucinous cardiomyopathy, ischemia and/or heart failure)
(5) myopathy
(6) fibromyalgia
(7) esophageal dysmotility
(8) bilateral macular edema
(9) Raynaud's phenomenon
(10) Sjogren syndrome
(11) dyspnea on exertion, decreased pulmonary diffusion capacity and/or pulmonary fibrosis
(12) hematologic disorder (myelodysplasia, lymphoma)
