A patient with rheumatoid arthritis may experience a number of extra-articular manifestations
Vasculitis/vasculopathy:
(1) systemic vasculitis
(2) cutaneous vasculitis (severe, benign, nail fold)
(3) glomerulonephritis
(4) retinal vasculitis
(5) pulmonary vasculitis
(6) Raynaud's phenomenon
(7) other organ-limited vasculitis
Inflammatory:
(1) pericarditis
(2) pleuritis
(3) polymyositis
(4) scleritis, episcleritis, kerato-conjunctivitis perforans
(5) secondary Sjogren's syndrome
(6) neuropathy (polyneuropathy, mononeuropathy, mononeuritis multiplex)
Other:
(1) Felty's syndrome
(2) lymphadenopathy
(3) rheumatoid nodules
(4) interstitial lung disease (ILD)
Complications:
(1) atlanto-axial or subaxial subluxation, cervical myelopathy
(2) chronic leg ulcers
(3) anemia
(4) osteoporosis
(5) carpal tunnel syndrome
(6) reflex sympathetic dystrophy
(7) cryoglobulinemia
(8) ischemic heart disease
(9) infection (septic arthritis, septicemia, pneumonia)
(10) non-Hodgkin's lymphoma
(11) secondary amyloidosis
(12) cachexia
