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Extent of Protein Binding

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care

Objective:

ICD-10:

Description:

The extent to which a drug is bound to plasma protein determines the fraction of drug that is active or which can be extracted by the eliminating organ(s).  Altered binding will change the various kinetics significantly only if they are limited to free drug in plasma. 

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