A patient with propionic or methylmalonic acidemia may show exercise intolerance that is linked to mitochondrial energy failure.
Patient selection: propionic or methylmalonic acidemia
Features:
(1) muscular hypotonia
(2) exercise intolerance with impaired stamina
(3) impairment in daily activities requiring exertion
The exercise intolerance tends to be worse during:
(1) acute metabolic decompensation (associated with fever, infection, trauma, stress, etc)
(2) chronic metabolic instability
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Specialty: Surgery, orthopedic
