Metabolic acidosis may develop during exercise due to accumulation of acids. This acidosis clears during recovery and may limit exercise if severe.


(1) In metabolic acidosis the pH and base excess should fall.

(2) With intense exercise there may be an accumulation of lactic acid (due to overproduction and/or under removal).


Conditions affecting generation of lactic acid:

(1) mitochondrial myopathy

(2) McArdle disease

(3) COPD and other conditions with hypoxia


In some patients ketoacidosis may also contribute to the metabolic acidosis.

To read more or access our algorithms and calculators, please log in or register.