Metabolic acidosis may develop during exercise due to accumulation of acids. This acidosis clears during recovery and may limit exercise if severe.
Features:
(1) In metabolic acidosis the pH and base excess should fall.
(2) With intense exercise there may be an accumulation of lactic acid (due to overproduction and/or under removal).
Conditions affecting generation of lactic acid:
(1) mitochondrial myopathy
(2) McArdle disease
(3) COPD and other conditions with hypoxia
In some patients ketoacidosis may also contribute to the metabolic acidosis.
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Specialty: Surgery, orthopedic
