Hypogonadotropic hypogonadism can rarely occur in a male endurance runner. This may be the male counterpart of the female athlete triad.

Typical patient: young male endurance runner, with intense exercise starting prior to sexual maturity


Presentations may include:

(1) infertility, erectile dysfunction or decreased libido

(2) osteopenia with fracture

(3) depressed mood


Laboratory findings:

(1) low serum LH and FSH

(2) low serum testosterone


It is important to exclude other causes of hypogonadotropic hypogonadism.


Therapeutic options may include testosterone replacement or clomiphene citrate.

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