Familial Mediterranean Fever (FMF) is one of the autoinflammatory periodic fevers. The Eurofever Project and PRINTO developed a score for identifying affected patients.
Patient selection: periodic fever
Parameters:
(1) chest pain
(2) duration of febrile episodes
(3) abdominal pain
(4) ethnicity
(5) aaphthous stomatitis
(6) urticarial rash
(7) enlarged cervical lymph nodes
(8) duration of episode (second use)
Parameter
Finding
Points
chest pain
yes
13
no
0
duration of fever in days
< 2 days
9
>= 2 days
0
abdominal pain
yes
18
no
0
ethnicity
Eastern Mediterranean
22
Northern Mediterranean
7
other
0
aphthous stomatitis
yes
0
no
9
urticarial rash
yes
0
no
15
enlarged cervical lymph nodes
yes
0
no
10
duration of episode
<= 6 days
13
> 6 days
0
where:
• Eastern Mediterranean: Turkish, Armenian, Arab, non-Ashkenazi Jew
• Northern Mediterranean: Spanish, Greek, Italian
total score =
= SUM(points for all 8 parameters)
Interpretation:
• minimum score: 0
• maximum score: 100
• A score >= 50 indicates a patient who may have FMF.
Performance:
• The area under the ROC curve was 0.98.
• The sensitivity ranges from 94 to 97% and specificity ranges from 91 to 98% (training and validation series).
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