EULAR/PReS reported consensus criteria for the diagnosis of polyarteritis nodosa (PAN) in a pediatric population.
Patient selection: pediatric patient
Pattern of vasculitis: inflammation predominantly of medium-sized blood vessels
Clinical criteria for the diagnosis of childhood PAN:
(1) one or both of the following:
(1a) biopsy evidence of necrotizing vasculitis affecting small or medium sized arteries
(1b) angiographic abnormalities (aneurysms, occlusions)
(2) two or more of the following:
(2a) skin lesions (livedo reticularis, tender subcutaneous nodules, other)
(2b) myalgia or muscle tenderness
(2c) systemic arterial hypertension based on blood pressure relative to pediatric reference ranges
(2d) mono- or polyneuropathy
(2e) impaired renal function (eGFR less than 50% of normal for age) and/or abnormal urinalysis
(2f) testicular pain or tenderness
(2g) evidence of vasculitis in other systems (cardiac, pulmonary, gastrointestinal, CNS)
where:
• If initial MR angiography is negative, then conventional angiography should be performed.
Hepatitis B associated PAN is classified as vasculitis secondary to infection under "other" vascultides.
