EULAR developed a disease activity index for primary Sjogren's syndrome called the ESSDAI. This consists of 12 subscores measuring various components of disease activity. The authors are from the European League Against Rheumatism Sjogren's Task Force.
Patient selection: primary Sjogren's syndrome
Stable long-standing changes are graded as "no activity".
Exclude renal disease due to other ause
Parameters for renal subscore:
(1) proteinuria in grams per day
(2) hematuria
(3) leukocyturia
(4) renal tubular acidosis
(5) GFR
(6) biopsy findings
|
Parameter |
Finding |
Points |
|
proteinuria |
< 0.5 g/day |
0 |
|
|
0.5 to 1.0 g/day |
1 |
|
|
1.0 to 1.5 g/day |
2 |
|
|
> 1.5 g/day |
3 |
|
hematuria |
absent |
0 |
|
|
present |
3 |
|
leukocyturia |
absent |
0 |
|
|
present |
2 |
|
renal tubular acidosis |
absent |
0 |
|
|
present |
2 |
|
GFR |
>= 60 mL.min |
0 |
|
|
< 60 mL/min |
3 |
|
biopsy findings |
normal |
0 |
|
|
extra-membranous GN |
2 |
|
|
interstitial lymphoid infilatrate |
2 |
|
|
proliferative GN |
3 |
|
|
cryoglobulinemia-related GN |
3 |
where:
• GN = glomerulonephritis
• Leukocyturia is mentioned when absent but not when present.
subscore weighting: 5
subscore for renal findings=
= MAX(points for the parameters) * (weighting)
Interpretation:
• minimum subscore: 0
• maximum subscore: 15
|
Subscore |
Disease Activity |
|
0 |
no |
|
5 |
low |
|
10 |
moderate |
|
15 |
high |
Specialty: Immunology/Rheumatology
