EULAR developed a disease activity index for primary Sjogren's syndrome called the ESSDAI. This consists of 12 subscores measuring various components of disease activity. The authors are from the European League Against Rheumatism Sjogren's Task Force.
Patient selection: primary Sjogren's syndrome
Exclusion: hematological changes due to other causes (nutritional, iron deficiency, drug-induced)
Parameters for constitutional subscore:
(1) autoimmune absolute neutropenia (per µL)
(2) autoimmune absolute lymphopenia (per µL)
(3) autoimmune anemia (hemoglobin in g/dL)
(4) autoimmune thrombocytopenia (per µL)
|
Parameters |
Findings |
Points |
|
autoimmune neutropenia |
> 1,500 per µL |
0 |
|
|
1,001 to 1,500 per µL |
1 |
|
|
500 to 1,000 per µL |
2 |
|
|
< 500 per µL |
3 |
|
autoimmune lymphopenia |
>= 1,000 per µL |
0 |
|
|
501 to 999 per µL |
1 |
|
|
<= 500 per µL |
2 |
|
hemoglobin |
>= 12 g/dL |
0 |
|
|
10.1 to 11.9 g/dL |
1 |
|
|
8 to 10 g/dL |
2 |
|
|
< 8 g/dL |
3 |
|
platelet count |
>= 150,000 per µL |
0 |
|
|
100,001 to 149,999 per µL |
1 |
|
|
50,000 to 100,000 per µL |
2 |
|
|
< 50,000 per µL |
3 |
subscore weighting: 2
subscore for hematological symptoms =
= MAX(points for the 4 parameters) * (weighting)
Interpretation:
• minimum subscore: 0
• maximum subscore: 6
|
Subscore |
Disease Activity |
|
0 |
No |
|
2 |
Low |
|
4 |
moderate |
|
6 |
High |
Specialty: Immunology/Rheumatology
