EULAR developed a disease activity index for primary Sjogren's syndrome called the ESSDAI. This consists of 12 subscores measuring various components of disease activity. The authors are from the European League Against Rheumatism Sjogren's Task Force.
Patient selection: primary Sjogren's syndrome
Parameters for biological subscore:
(1) complement levels
(2) gamma globulin levels
(3) cryoglobulin
Parameters |
Findings |
Points |
complement levels |
normal |
0 |
|
clonal |
1 |
|
decreased (low C3, C4 or CH50) |
1 |
gamma globulin |
normal |
0 |
|
elevated with IgG level 16 to 20 g/L |
1 |
|
elevated with IgG level > 20 g/L |
2 |
|
decreased with IgG level < 5 g/L |
2 |
cryoglobulin |
absent |
0 |
|
present |
2 |
subscore weighting: 1
subscore for constitutional symptoms =
= MAX(points for the parameters) * (weighting)
Interpretation:
• minimum subscore: 0
• maximum subscore: 2
Subscore |
Disease Activity |
0 |
no |
1 |
low |
2 |
moderate |
Specialty: Immunology/Rheumatology