Clinical manifestations of excess estrogen production:
(1) precocious puberty
(2) endometrial hyperplasia
(3) postmenopausal bleeding
Classes of ovarian tumors associated with estrogen production:
(1) sex cord-stromal tumors
(2) steroid cell
(3) ovarian tumors with functional stroma
Sex cord-stromal tumors associated with estrogen production:
(1) granulosa cell tumor, adult type
(2) granulose cell tumor, juvenile type
(3) thecoma
(4) sclerosing stromal tumor (few)
(5) sex cord tumor with annular tubules (some)
Steroid cell tumors
(1) stromal luteoma
(2) hilus cell tumor, C- type
(3) steroid cell tumor (few)
Ovarian tumors with functional stoma (contain scattered luteinized stromal cells):
(1) mucinous cystadenoma or cystadenocarcinoma
(2) serous cystadenoma or cystadenocarcinoma
(3) Brenner tumor (few)
(4) metastatic carcinoma
(5) clear cell carcinoma
(6) endometrioid carcinoma
