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Estimation of the Initial Drug Concentration in the Two Compartment Model

Specialty:

Toxicology
Emergency Medicine
Critical Care

Objective:

ICD-10:

Description:

During the second phase of a biphasic system the drug concentration follows first order kinetics. Sometimes the semilogarithmic line of drug concentration vs time is extrapolated back to time 0 to determine a theoretical initial concentration that would have been present if the drug followed a single compartment model.

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