
Estimation of the Initial Drug Concentration in the Two Compartment Model
Specialty: | Toxicology Emergency Medicine Critical Care |
Objective: | |
ICD-10: | |
Description: | During the second phase of a biphasic system the drug concentration follows first order kinetics. Sometimes the semilogarithmic line of drug concentration vs time is extrapolated back to time 0 to determine a theoretical initial concentration that would have been present if the drug followed a single compartment model. |
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