Schutte et al estimated the total striated muscle mass based on plasma volume and the plasma creatinine level. The authors are from the University of Texas Southwestern in Dallas.
total plasma creatinine in mg =
= (plasma volume in deciliters) * (plasma creatinine in mg/dL)
estimated muscle mass in kilograms =
= 0.88 * (total plasma creatinine in mg)
• In an experimental model with dogs, the predicted value was with +/- 3.9% of the observed value (0.5 to 10.8%).
• A patient with renal insufficiency has an elevated plasma creatinine unrelated to sketelal muscle mass.
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