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Estimating the Risk of Recurrence in a Relative When One Person Affected

Purpose:

To get a rough estimate of the recurrence risk for a condition with a known population frequency and only one relative affected.

Specialty:

Genetics

Objective:

risk factors

ICD-10:

C00-D49, Q00-Q99

Description:

If a single relative has an inherited condition, then a patient may be concerned about his or her risk of developing that condition. Edwards developed a quick estimate for the risk to the patient that uses the population frequency of the condition and the relationship of the person to the affected relative. It is based on the assumption that each degree of relationship halves the correlation between relatives.

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