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Estimating the Plasma Level of Propylene Glycol from Osmolal Gap

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care

Objective:

ICD-10:

Description:

Propylene glycol (1,2-propanediol) is solvent used in many intravenous medications. While normally nontoxic, it can result in hyperosmolality with a metabolic acidosis when large volumes of these medications are administered relative to the patient's plasma volume. The concentration of propylene glycol can be estimated from the osmolal gap.

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