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Estimating the Plasma Level of Propylene Glycol from Osmolal Gap

Description

Propylene glycol (1,2-propanediol) is solvent used in many intravenous medications. While normally nontoxic, it can result in hyperosmolality with a metabolic acidosis when large volumes of these medications are administered relative to the patient's plasma volume. The concentration of propylene glycol can be estimated from the osmolal gap.


 

Molecular weight of propylene glycol: 76.08 g

 

predicted osmolal gap in mOsm per Kg H2O =

= (2 * (serum sodium concentration in mEq/L)) + ((serum glucose in mg/dL) / 18) + ((serum BUN in mg/dL) / 2.8)

 

osmolal gap =

= (measured osmolal gap) – (predicted osmolal gap)

 

Equation of Glasgow et al

 

propylene glycol in mg/dL =

= (9.2 * (osmolal gap)) + 47.5

 

Equation of Fligner et al

 

predicted osmolal gap in mOsm per Kg H2O =

= (1.86 * (serum sodium concentration in mEq/L)) + ((serum glucose in mg/dL) / 18) + ((serum BUN in mg/dL) / 2.8)

 

osmolal gap =

= (measured osmolal gap) – ((predicted osmolal gap) / 0.93)

 

propylene glycol in mg/dL =

= (7.8 * (osmolal gap)) + 84.6

 

Based on Chemical Formula

 

propylene glycol in mg/dL =

= (osmolal gap) * 7.6

 

propylene glycol in mmol/L =

= (osmolal gap)

 


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