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Estimating Gene Frequencies at Equilibrium When Being a Heterozygote is an Advantage Over Being Homozygote for a Trait

Specialty:

Genetics

Objective:

ICD-10:

Description:

Sometimes being heterozygous for a gene confers a genetic benefit relative to being homozygous for either of the 2 alleles. As demonstrated by Fisher in 1922, when this occurs in a population with random matings a stable balanced polymorphism will be reached and maintained. The equilibrium gene frequencies will be dependent on the relative extent to which the heterozygote is fitter than either of the two homozygote states.

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