Patient parameters used to estimate the carboplatin clearance:
(1) weight in kilograms
(2) sex
(3) age
(4) serum creatinine in µmol/L
estimated carboplatin clearance in mL/min =
= (0.134 * (weight in kilograms)) + ((218 * (weight in kilograms)) * (1 – (0.00457 * (age in years))) * (1 – (0.314 * (points for sex))) / (serum creatinine in µmol/L))
where:
• Sex is assigned a value of 0 if male and 1 if female.
• The serum creatinine is stated to be in micromolar concentration. I am assuming this is per liter, since that is the SI units.
• I did not see if the body weight was adjusted if the patient was obese.
Once the carboplatin clearance is known, it is possible to estimate the appropriate dose to achieve a specific AUC as:
dose of carboplatin in mg =
= (target AUC in mg • min/mL) * (carboplatin clearance in mL/min)
Performance:
• The formula predicted the actual carboplatin clearance with a median absolute percent error of 10% (range 0% to +30%) and a median percent error of 2% (range –25% to +30%).
