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Estimating Aluminum Content in Bone from the Length of Stainable Aluminum

Description

The amount of aluminum in bone from a patient with renal osteodystrophy can be estimated by the length of aluminum staining in a bone biopsy. Ott et al developed an equation that correlated this length with measurements done by flameless atomic absorption spectrophotometry.


 

Aluminum stain: aurin tricarboxylic acid, with differentiation in ammonium carbonate buffer.

 

Parameters:

(1) area of tissue examined in square mm (including bone and medullary space)

(2) length of aluminum staining in mm with tissue area examined

 

Minimum tissue area examined: 12 square mm

 

aluminum in mg per kg dry bone weight -

= (69 * (length of stainable aluminium per square mm tissue area)) + 42

 

aluminum in mmol per kg bone weight =

= (aluminum in mg) / 26.98

 

1 mole of aluminum = 26.98 grams

 


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