### Description

Linderkamp et al derived equations for estimating the blood volume in infants and children <= 14 years of age. The lowest error in prediction was found with ones based multiple regression equation relating the logarithm of blood volume to combined height and logarithm of the weight.

Patient selection:

(1) 160 infants and children from 1 hour to 14 years of age from Germany

(2) Patients were excluded if they had a disease affecting blood volume, plasma volume or red blood cell mass.

(3) Newborn infants had early cord clamping.

NOTE: Lean body mass is better than actual weight for measuring blood volume in children.

Age

Gender

Blood Volume in mL/kg

0 - 1 day

81.9 +/- 8.6

2 - 30 days

84.4 +/- 7.5

1 - 2 months

79.4 +/- 6.9

3 - 6 months

76.6 +/- 9.0

7 - 12 months

82.4 +/- 10.4

13 - 24 months

86.1 +/- 9.7

2 -3 years

M

80.5 +/- 8.7

F

79.0 +/- 7.3

4 - 6 years

M

76.7 +/- 6.3

F

77.4 +/- 4.3

7 - 10 years

M

79.6 +/- 7.1

F

72.7 +/- 6.2

11 -14 years

M

74.4 +/- 5.2

F

68.3+/- 3.5

Table 1, page 228

Group I: Infants and Children < 2 Years of Age

LOG10 (blood volume in mL) =

= (0.7891 * (LOG10(body weight in kilograms))) + (0.004132 * (height in cm)) + 1.8117

error: 10.1%

Group II: Boys Aged 2-14 years, and Girls Aged 2-6 Years

LOG10 (blood volume in mL) =

= (0.6459 * (LOG10(body weight in kilograms))) + (0.002743 * (height in cm)) + 2.0324

error: 4.8%

Group III: Girls Aged 7-14 Years

LOG10 (blood volume in mL) =

= (0.6412 * (LOG10(body weight in kilograms))) + (0.001270 * (height in cm)) + 2.2169

error: 7.5%

Additional Equations Using a Single Body Size Measure

(Table 2, page 229)

Group

Equation

r value

% error

I

blood volume in mL = (84.9 * (body weight in kilograms)) - 10

0.963

11.8%

blood volume in mL = (20.3 * (height in cm)) - 772

0.950

11.6%

blood volume in mL = (2,147 * (BSA in square meters)) - 179

0.964

12.2%

log10 (blood volume in mL) = (0.019550 * (height in cm)) + 1.4162

0.944

16.9%

log10 (blood volume in mL) = (0.9795 * (log10(weight in kilograms))) + 1.9318

0.974

10.9%

log10 (blood volume in mL) = (2.7862 * (log10(height in cm))) - 2.3427

0.955

14.2%

log10 (blood volume in mL) = (1.4062 * (log10(BSA in square meters))) + 3.3846

0.973

11.9%

II

blood volume in mL = (73.9 * (body weight in kilograms)) + 73

0.983

5.1%

blood volume in mL = (36.9 * (height in cm)) - 2580

0.945

5.9%

blood volume in mL = (2,916 * (BSA in square meters)) - 761

0.979

4.8%

log10 (blood volume in mL) = (0.008070 * (height in cm)) + 2.2537

0.974

6.5%

log10 (blood volume in mL) = (0.9699 * (log10(weight in kilograms))) + 1.9278

0.978

5.5%

log10 (blood volume in mL) = (2.2461* (log10(height in cm))) - 1.4277

0.963

6.7%

log10 (blood volume in mL) = (1.3656 * (log10(BSA in square meters))) + 3.3190

0.985

4.6%

III

blood volume in mL = (53.8 * (body weight in kilograms)) + 552

0.954

8.4%

blood volume in mL = (37.2 * (height in cm)) - 2851

0.932

17.6%

blood volume in mL = (2,478 * (BSA in square meters)) - 488

0.969

9.6%

log10 (blood volume in mL) = (0.006867 * (height in cm)) + 2.4048

0.949

9.3%

log10 (blood volume in mL) = (0.7790* (log10(weight in kilograms))) + 2.1852

0.958

7.9%

log10 (blood volume in mL) = (2.1843 * (log10(height in cm))) - 1.3188

0.940

10.9%

log10 (blood volume in mL) = (1.1984 * (log10(BSA in square meters))) + 3.2990

0.971

7.9%

percent error from Table 4, page 231