Huguier described a deformity of the genitalia caused by an unknown sexually-transmitted disease (STD), using the term esthiomene to distinguish it from more common conditions.
Clinical features:
(1) leaden or violaceous color
(2) hypertrophy, thickening and induration
(3)) variable ulceration
(4) deformity with or without urethral stricture
(5) absence of pain or tenderness
Conditions associated with esthiomene:
(1) lymphogranuloma venereum (LGV)
(2) possibly granuloma inguinale
Exclusions:
(1) cutaneous tuberculosis (lupus vulgaris)
(2) syphilis
(3) CLL or other lymphoproliferative disorder
(4) other malignancy
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