The erythropoietin resistance index (ERI) is an indication of erythropoietin resistance in a patient with end-stage renal disease. It can be trended over time.
Patient selection: end-stage renal disease receiving erythropoietin
Parameters:
(1) weekly dose of erythropoietin in units
(2) hemoglobin concentration in g/dL
(3) post hemodialysis weight in kilograms
ERI =
= (weekly dose of erythropoietin in units) / ((weight) * (hemoglobin)
Units: units per week per kg per g/dL
A similar index can be generated for darbopoietin but the units would be different.
Interpretation:
• The higher the index (high dose, low hemoglobin) the greater the erythropoietin resistance.
• An ERI from 0 to 5 would be considered low (Bae et al).
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Specialty: Hematology Oncology, Pharmacology, clinical, Nephrology
