Erectile dysfunction (ED) is common in males with acromegaly, possibly due to the effect of growth hormone on the nitric oxide cyclic guanosine monophosphate pathway.
Severe ED tends to be seen in patients with a longer disease duration.
Endocrine factors:
(1) hypogonadotropic hypogonadism
(2) hyperprolactinemia
(3) diabetes
Cardiovascular comorbidities:
(1) cardiomyopathy
(2) hypertension
Other risk factors:
(1) smoking
(2) sleep apnea
(3) depression
(4) drugs
Control of growth hormone secretion and other risk factors can improve erectile function.
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