Equations of Schlimp et al for Predicting Plasma Fibrinogen in the Emergency Room Following Major Trauma

 

Patient selection: major trauma on admission to the Emergency Room

 

Parameters:

(1) hemoglobin in g/dL

(2) base excess (BE) in mmol/L (negative in metabolic acidosis)

(3) injury severity score (ISS)

 

X =

= (0.223 * (hemoglobin)) - (0.007 * ((hemoglobin)^2)) + (0.044 * (base excess)) + 3.567

 

Y =

= (0.243 * (hemoglobin)) - (0.008 * ((hemoglobin)^2)) + (0.036 * (base excess)) - (0.031 * (ISS)) + (0.0003 * ((ISS)^2)) + 4.188

 

fibrinogen in mg/dL =

= EXP(X)

= EXP(Y)

 

The percent of patients with a significant decrease in plasma fibrinogen increased as the base excess declined. A fibrinogen < 150 mg/dL was seen in 63% of patients with a base excess less than -6 mmol/L vs 78% with a base excess less than 10 mmol/L.