al developed equations describing the effect of a dose of carboplatin on the platelet count of a patient with impaired renal function. The authors are from the University of Maryland.
Synonyms for carboplatin: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum, NSC 241240
Parameters:
(1) body surface area in square meters
(2) pretreatment platelet count
(3) creatinine clearance in mL/min
(4) history of heavy pretreatment with myelosuppressive drugs
dose in mg per square meter BSA if previously untreated =
= (0.091 * (creatinine clearance) / (body surface area) * ((pretreatment platelet count) – (desired nadir platelet count)) / (pretreatment platelet count) * 100) + 86
dose in mg per square meter BSA if previously treated with myelosuppressive drug =
= (0.091 * (creatinine clearance) / (body surface area) * ((((pretreatment platelet count) – (desired nadir platelet count)) / (pretreatment platelet count) * 100) – 17)) + 86
