Equation of Wiley and Koepke for Predicting Hematocrit Rise in a Premature Infant After Blood Transfusion

Parameters:

(1) hematocrit at baseline

(2) hematocrit target

(3) weight in kilograms

hematocrit rise =

= (target hematocrit) - (baseline hematocrit)

If the packed red cell volume of the blood product is 0.75:

mL of packed red blood cells transfused =

= 4/3 * (desired hematocrit rise) * (weight in kilograms)

If the packed red cell volume of the blood product is 0.66:

mL of packed red blood cells transfused =

= 3/2 * (desired hematocrit rise) * (weight in kilograms)

where:

• The blood volume of a full-term neonate is about 85 mL / kg.

• For premature infants, the blood volume is 108 mL / kg.