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Equation of Parry for Correcting a Serum Creatinine Concentration Determined by the Jaffe Method for Albumin

Description

The creatinine concentration determined by the Jaffe reaction (alkaline picrate method) may be affected by a number of compounds such as protein that form chromogenic compounds. Use of a single value to compensate for this interference can result in significant error if the albumin is very high or low. Parry developed an equation that can accurately determine what compensation to use.


 

If the analytic method uses a single value (for example the Roche factor of 26 µmol/L) then the reported value for serum creatinine may be low if the serum albumin is low or too high if the serum albumin is high.

 

Parameters:

(1) concentration of creatinine by the Jaffe reaction in µmol/L

(2) serum albumin in g/L (albumin is the protein that causes most of the interference)

 

value to subtract from the creatinine reading in µmol/L =

= (0.544 * (serum albumin in g/L)) + 4.075

 

serum creatinine concentration corrected for protein =

= (original concentration) - (value to compensate for protein content)

 


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Specialty

ICD-10