Nicholson et al developed an equation for predicting the dose of digozin required by a patient. The authors are from The Middlesex Hospital Medical School, University of Manchester, and Tameside General Hospital in England.
Parameters:
(1) inpatient vs outpatient
(2) body weight in kilograms
(3) serum creatinine in µmol/L
(4) mobility
(5) gender
(6) age
(7) heart rhythm
(8) diuretic treatment
|
Parameter |
Finding |
Points |
|
inpatient vs outpatient |
inpatient |
1 |
|
|
outpatient |
2 |
|
weight |
< 55 kg |
1 |
|
|
55 to 64.9 kg |
2 |
|
|
65 to 74.9 kg |
3 |
|
|
>= 75 kg |
4 |
|
serum creatinine |
< 70 µmol/L |
1 |
|
|
70 to 99 µmol/L |
0.5 |
|
|
100 to 199 µmol/L |
0.33 |
|
|
>= 200 µmol/L |
0.25 |
|
mobility |
chronically home or chair bound |
1 |
|
|
other |
2 |
|
gender |
female |
1 |
|
|
male |
2 |
|
age in years |
< 70 years |
1 |
|
|
>= 70 years |
2 |
|
heart rhythm |
normal sinus rhythm |
1 |
|
|
other |
2 |
|
diuretic treatment |
none |
1 |
|
|
prescribed |
2 |
X =
= (0.2057 * (points for inpatient)) + (0.0608 * (points for weight)) + (0.5443 * (points for creatinine)) + (0.1429 * (points for mobility)) + (0.084 * (points for gender)) - (0.0974 * (points for age)) - (0.0481 * (points for heart rhythm)) - (0.049 * (points for diuretic)) – 1.5141
maintenance dose in mg =
= 10^X
Specialty: Toxicology, Emergency Medicine, Critical Care, Cardiology
