Equation of Lee et al for Estimating the Increase in Hemoglobin Following a Blood Transfusion to a Hemodynamically Stable Patient in the Emergency Department

 

Parameters:

(1) pretransfusion hemoglobin in g/dL

(2) volume of blood transfused in mL

(3) body surface area (BSA) in square meters

 

estimated increase in hemoglobin following transfusion in g/dL =

= (0.24 * (volume of blood transfused) / 100) - (0.31 * (pretransfusion hemoglobin)) - (1.71 * (body surface area)) + 5.43

 

Performance:

• The adjusted R-squared was 0.66.

• The plot of observed vs estimated increase in hemoglobin had an r = 0.73 with interclass correlation = 0.84.

 

This equation can be rearranged to give the volume of blood that needs to be transfused to give a desired rise in hemoglobin:

 

volume of blood to transfuse in mL =

= 416.67 * ((desired rise in hemoglobin in g/dL) - 5.43 + (1.71 * (BSA)) + (0.31 * (pretransfusion hemoglobin))) =

= (416.67 * (desired rise in hemoglobin in g/dL)) + (712.56 * (BSA)) + (129.17 * (pretransfusion hemoglobin)) - 2262.5