Hoogeveen et al estimated the volume of donor blood required to transfuse during an intrauterine blood transfusion. The authors are from Leiden University in The Netherlands.
Method: Intrauterine blood transfusions were performed using the umbilical vein. Fetal blood was sampled before and after donor blood infusion.
(1) estimated fetoplacental blood volume in mL
(2) donor hematocrit as a decimal fraction from 0 to 1
(3) initial fetal hematocrit as a decimal fraction from 0 to 1 before transfusion
(4) fetal hematocrit as a decimal fraction from 0 to 1 after transfusion (target hematocrit)
volume of donor blood to infuse in mL =
= (fetoplacental blood volume in mL) * ((final target fetal hematocrit) - (initial fetal hematocrit)) / ((donor hematocrit) - (0.70 * (final target fetal hematocrit)))
The donor blood was transfused at a rate of 3-5 mL per minute.
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Purpose: To determine the volume of donor blood to use for an intrauterine blood transfusion using the equation of Hoogeveen et al.
Specialty: Clinical Laboratory, Pedatrics, Obstetrics & Gynecology
Objective: dosage calculations