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Equation of Coleman et al for Calculating the Free Phenytoin Concentration at 37°C Based on Testing at Room Temperature

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care
Neurology, Psychiatry, Ophthalmology & Otolaryngology

Objective:

ICD-10:

Description:

The binding of phenytoin to albumin is temperature dependent. Coleman et al developed an equation for estimating the free phenytoin concentration at 37°C based on the level seen in the laboratory at 25°C.

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