Description

Azizova et al developed an equation correlating the absolute neutrophil count within 2-3 hours following a radiation exposure with the acute dose. The authors are from Southern Urals Biophysics Institute, the University of Pittsburgh, Mayak Production Association, and the University of California Davis.


The neutrophil count tends to increase within a few hours of a radiation exposure, A neutrophilia > 12,000 per µL correlates with severity group IV. Group IV patients tend to show a bimodal pattern over the first week. Neutropenia may develop in Group III or IV about a week after the exposure.

 

Parameters:

(1) absolute neutrophil count within 2-3 hours after a radiation exposure

(2) acute radiation dose in Gy

 

absolute neutrophil count in 10^9/L =

= 4.94 + (4.66 * LOG10(absorbed dose in Gy))

 

If this is rearranged:

 

absorbed dose in Gy =

= 10^((absolute neutrohil count in 10^9/L) - 4.94) / 4.66) =

= 10^((0.215 * (absolute neutrophil count)) - 1.06)

 

LOG10(dose)

Radiation Dose

Severity Group (Guskova and Baysogolov)

< 0

1 Gy

0

0 to 0.3

1 - 2 Gy

I

0.3 to 0.6

2 - 4 Gy

II

0.6 to 0.8

4 - 6.3 Gy

III

> 0.8

> 6.3 Gy

IV

 


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