Lichtinghagen et al reported on the use of the enhanced liver fibrosis (ELF) score for evaluating a patient with chronic hepatitis C for liver fibrosis. The authors are from Hannover Medical School and Sana Kliniken Lubeck in Germany.
Patient selection: viral hepatitis C, chronic liver diseases
Outcome: significant hepatic fibrosis
Parameters:
(1) N-terminal procollagen III propeptide (PIIINP) in ng/mL
(2) tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) in ng/mL
(3) hyaluronic acid (HA) in ng/mL
Testing for biomarkers was performed on the ADVIA Centaur CP immunohistochemical analyzer.
discriminant function for fibrosis =
= (0.846 * LN(HA)) + (0.735 * LN(PIIINP)) + (0.391 * LN(TIMP-1)) + 2.494
Cutoffs for various values
Score
Hepatic Fibrosis
below 7.7
unlikely
9.8
fibrosis present
> 11.3
cirrhosis
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Specialty: Gastroenterology, Infectious Diseases
