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Endothelial Activation and Stress Index (EASIX) of Luft et al in Acute Graft-versus-Host Disease (GVHD)

Description

Luft et al used the Endothelial Activation and Stress Index (EASIX) to evaluate patients with graft-versus-host disease after allogeneic stem-cell transplants. The authors are from University Hospital Heidelberg, German Cancer Research Center, Cincinnati Children's Hospital, University of Washington and Charite University Medicine Berlin.


Parameters:

(1) serum LDH in U/L

(2) serum creatinine in mg/dL

(3) platelet count in 10^9/L

 

EASIX =

= (serum LDH) * (serum creatinine) / (platelet count)

 

In patients with reduced-intensity conditioning EASIX is predictive of overall survival.

 

In patients with myeloablative conditioning EASIX was not predictive due to the reduction in platelet count associated with myeloablation.


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