Higgins et al listed end points for various disease activity indices that correlate with clinical improvement and remission for a patient with ulcerative colitis. The authors are from the University of Michigan at Ann Arbor.
Disease activity indices evaluated:
(1) St. Mark's (index of Powell-Tuck et al, 10.17.25)
(2) ulcerative colitis disease activity index (UCDAI, of Sutherland et al, 10.17.28)
(3) simple clinical colitis activity index (SCCAI, of Walmsley et al, 10.17.21)
(4) Seo score (10.17.20)
(5) inflammatory bowel disease quality of life index (IBDQ, 01.22.01)
(6) 7 point Likert scale (from much better to much worse)
|
Instrument |
Normal |
Most Abnormal |
|
St. Mark's |
0 |
20 or 22 |
|
UCDAI |
0 |
12 |
|
SCCAI |
0 |
20 |
|
Seo |
around 100 |
around 300 |
|
IBDQ |
224 |
32 |
|
7-point Likert |
1 |
7 |
change in value =
= (current value) - (previous value)
|
Instrument |
Absolute Value Indicating Remission |
Change in Value for Clinical Improvement |
|
St. Mark's |
< 3.5 |
|
|
UCDAI |
< 2.5 |
|
|
SCCAI |
< 2.5 |
decrease > 1.5 |
|
Seo |
< 120 |
decrease > 30 |
|
IBDQ |
> 205 |
increase > 20 |
In addition, a value of 1 (much better) or 2 (somewhat better) on a 7-point Likert scale indicated clinical improvement.
Specialty: Gastroenterology
