END-IT Score of Gao et al for Predicting Functional Outcome for a Patient with Convulsive Status Epilepticus

 

Patient selection: > 12 years of age with convulsive status epilepticus (continuous motor seizure activity OR recurrent seizure activity without regaining full consciousness between episodes)

 

Exclusion: cerebral anoxia (due to high mortality rate)

 

Outcome: unfavorable (modified Rankin scale 3 to 6, ranging from dependence to death)

 

Parameters (END-IT):

(1) encephalitis (E)

(2) concurrent nonconvulsive status epilepticus (N)

(3) diazepam resistance (D)

(4) imaging studies (I)

(5) tracheal intubation (T)

 

Parameter	Finding	Points
encephalitis	No	0
	Yes	1
nonconvulsive SE	No	0
	Yes	1
diazepam resistance	No	0
	Yes	1
imaging studies	no responsible lesion	0
	unilateral lesion	1
	bilateral lesion or diffuse cerebral edema	2
tracheal intubation	No	0
	Yes	1

 

total score =

= SUM(points for all 5 parameters)

 

Interpretation:

• minimum END-IT score: 0

• maximum END-IT score: 6

• The higher the score the greater the chance of an unfavorable outcome.

 

If Figure 2 is modeled as a logistic regression model:

 

X = (-0.01803 * ((score)^2)) + (1.209 * (score)) - 3.478

 

probability of an unfavorable outcome =

= 1 / (1 + EXP((-1)*X))