Description

An enzyme-linked immonosorbent assay (ELISA) can be used to detect anticysticercal antibodies. Although a potential aid for diagnosis, several pitfalls exist that can trap the unwary.


 

False positive ELISA tests can occur in:

(1) a patient with schistosomiasis

(2) a patient with echinococcosis

(3) a patient with Taenia saginata infection

(4) a patient with filariasis

(5) with the presence of heterophile antibodies

 

False negative ELISA tests can occur in:

(1) a significant percentage of patients with cysticercosis, especially those with mild disease

 

A positive ELISA test can be helpful in the diagnosis of cysticercosis, but the diagnosis should not be excluded on the basis of negative serology.

 

A better test for diagnosing cysticercosis is the enzyme-linked immunoelectrotransfer blot (EITB) assay using purified antigens. This is highly specific and more sensitive than the ELISA assay.

 


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