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Half-Lives of AST & ALT Relative to Hepatocellular Injury

Purpose:

To evaluate a patient who has had a hepatocellular injury by monitoring the decline in serum transaminases over time with first order kinetics.

Specialty:

Gastroenterology

Objective:

laboratory tests, disease progression

ICD-10:

S36.1, R94.5

Description:

The transaminases aspartate aminotransferase (AST, SGOT) and alanine aminotransferase (ALT, SGPT) are released from hepatocytes following injury. If an injury is transient then the serum levels should decline to normal according to the protein kinetics.

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