Leukoreduction of blood products is done for a variety of reasons, the most common being prevention of febrile transfusion reactions. Quantitating white cells before and after the leukoreduction procedure is used to assess the adequacy of the procedure. The residual content of white cells is the number of leukocytes remaining in a product after leukoreduction.
percent leukocyte removal efficiency =
= (1 - ((leukocyte count after processing) / (leukocyte count before processing))) * 100
log reduction in white cells =
= log10 ((leukocyte count before processing) / (leukocyte count after processing)) * 100
residual white cell content of product =
= (leukocyte count per µL) * (1000 µL per mL) * (volume of product in mL)
Interpretation:
• to prevent febrile nonhemolytic transfusion reactions, the residual white cell count of a product should be under 5 * 10^8
• for other purposes, the residual white cell count of a product should be under 5 * 10^6
• The leukoreduction procedure on red cell products should not reduce the red cell content to less than 80% of the original content.
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