Cocaine abuse can have a number of adverse effects on the placenta and a pregnancy.


The risk of an adverse effect is affected by:

(1) timing of the abuse relative to the gestation (especially the first trimester)

(2) duration

(3) amount abused

(4) other drugs abused

(5) lack of prenatal care

(6) comorbid conditions (HCV, HIV, etc)


Complications of cocaine abuse may include:

(1) abruptio placentae

(2) intra-uterine fetal demise

(3) intra-uterine growth retardation

(4) preterm delivery

(5) fetal distress

(6) chorionic villus hemorrhage and/or edema

(7) chronic villitis

(8) placental infarcts


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