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Effect of Polymorphism in Cytidine Deaminase on the Pharmacokinetics of Gemcitabine

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care
Nephrology, Urology, Obstetrics & Gynecology, Pedatrics, Genetics

Objective:

ICD-10:

Description:

Gemcitabine is a chemotherapeutic nucleoside that halts DNA synthesis after it is incorporated into an elongating DNA strand. The metabolism of gemcitabine may be affected by polymorphisms in cytidine deaminase.

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