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Description

Echinococcosis may be more severe and accelerated in a patient who is significantly immunosuppressed. Evasion of host defenses is important for the organism's survival in a host, and the absence of key defenses allows larvae to proliferate.


 

Immunosuppression may take the form of:

(1) HIV disease

(2) transplant recipient

(3) hereditary immunodeficiency

(4) chronic therapy with corticosteroids

(5) therapy with targeted anti-immune agent (anti-TNF, other)

(6) possibly pregnancy

 

The patient may present with:

(1) recurrence of echinococcosis from a dormant focus

(2) progression of existing foci

(3) systemic dissemination

 

Monitoring of the patient may involve:

(1) PET scan

(2) serial titers of IgG antibodies to echinococcosis

 

Management may involve:

(1) reduction in immunosuppressive therapy

(2) therapy for an immunodeficiency

(3) chronic therapy with benzimidazole (parasitostatic agent)

(4) theoretically interferon alpha

 


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