ECG Changes Associated with Chemotherapy Using Tyrosine Kinase Inhibitors (TKI)

Possible mechanism: may affect the venticular action potential

ECG changes may include:

(1) sinus bradycardia

(2) QTc prolongation with or without Torsade de pointe

(3) atrial fibrillation

(4) ventricular tachycardia

(5) atrioventricular block

(6) ischemia and infarction

Other cardiac problems associated with TKI:

(1) hypertension

(2) left ventricular dysfunction

(3) chronic heart failure

Risk factors:

(1) pre-existing conditions or medications that prolong the QTc

(2) prior coronary artery disease

(3) history of anthracycline therapy

(4) heart failure

(5) diabetes