Colorectal carcinoma typically affects adults over the age of 50 years. Some patients may develop a colorectal carcinoma at an earlier age, with some below 40 years.
Features of early-onset colorectal cancer:
(1) poorly differentiated with aggressive behavior
(2) more often left-sided or rectal
Predictors for early-onset colorectal cancer:
(1) family history of colorectal cancer
(2) ethnic background
(3) hereditary syndrome associated with colorectal cancer
(4) inflammatory bowel disease (IBD)
(5) comorbidities (obesity, smoking, diabetes)
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