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Early Laboratory Tests Patterns of Potts et al Predictive for Severe Dengue Fever in Pediatric Patients

Description

Potts et al identified early laboratory indicators of severe dengue fever in Thai pediatric patients. This can help to identify a patient who may benefit from more aggressive managment. The authors are from University of Massachusetts, Armed Forces Research Institute of Medical Sciences in Bangkok, and Queen Sirikit National Institute of Child Health in Bangkok.


 

Patient: pediatric Thai with early dengue fever (within 72 hours of fever onset)

 

Parameters:

(1) white blood cell count

(2) percent monocytes in the differential count

(3) platelet count per microliter

(4) hematocrit in percent

 

These were studied using CART (classification and regress tree) analysis.

 

Pattern1 associated with severe dengue fever:

(1) WBC count <= 8,500 per µL

(2) percent monocytes <= 9%

(3) platelet count <= 160,200 per µL

 

Pattern 2 associated with severe dengue fever

(1) WBC count <= 8,500 per µL

(2) percent monocytes <= 9%

(3) platelet count > 160,200 per µL

(4) hematocrit <= 40%

 

where:

• Monocyte counts show interobserver variability.

 


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