Murase and Ishida studied preterm infants with early hypocarbia. These infants may be at risk for a number of problems. The authors are from Kakogawa Municipal Hospital in Kakogawa, Japan.


Patient selection: preterm infant with birthweight < 1,500 grams admitted to the neonatal intensive care unit


Criteria for early hypocarbia: PaCO2 < 3.3 kPa (25 mm Hg) in 2 or more specimens taken at 3, 6, 12, 24 and 48 hours after delivery.


Risk factors:

(1) history of maternal unintended fetal loss

(2) birthweight < 750 grams



(1) late onset periventricular leukomalacia (onset 15 days or more after birth)

(2) cerebral palsy, often of a spastic type

(3) septicemia (Table II)


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