A patient with Parkinson's disease may develop motility disorders in the esophagus and stomach due to autonomic dysfunction and other disorders of the nervous system. These can result in a number of bothersome problems for the patient.


Clinical manifestation of esophageal dysmotility:

(1) drooling (due to a combination of increased salivation and decreased swallowing)

(2) dysphagia

(3) gastroesophageal reflux disease (GERD)

(4) recurrent aspiration

(5) esophageal spasms

(6) aerophagia

(7) difficulty swallowing oral medications, liquids and/or food


Clinical manifestations of gastroparesis:

(1) nausea

(2) bloating

(3) early satiety

(4) weight loss

(5) fluctuation in the effect of oral levodopa


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