Drugs, Herbs and Chemicals Associated with Hyperprolactinemia

 

Chemicals (including heavy metals)

(1) manganese

(2) organic mercury

(3) lead

(4) cadmium

(5) uranium

(6) arsenic

(7) barium

(8) styrene

(9) perchloroethylene

 

Herbal medicines:

(1) Acacia nilotica ssp adansonii

(2) Cimicifuga racemose

(3) Echinacea purpurea

(4) Hypericum perforatum

(5) Purariae isoflavone

 

Drugs:

(1) anesthetic gases

(2) antidepressants

(3) antihypertensive drugs (verapamil, methyldopa, reserpine)

(4) H2 blockers

(5) metoclopramide

(6) domperidone

(7) opiates

(8) estrogens

(9) protease inhibitors

(10) neuroleptics (phenothiazins, butyrophenone, atypical antipsychotic agents)

 

Drugs of potential abuse:

(1) cocaine

 

Demonstration of effect:

(1) no evidence of hyperprolactinemia prior to exposure

(2) elevated serum prolactin or evidence of hyperprolactinemia during therapy

(3) normalization of changes after discontinuation of the exposure