Drugs other than insulin and the oral hypoglycemic agents (sulfonylureas, thiazolidinedione, metformin, meglitinide, alpha-glucosidase inhibitors) may be associated with hypoglycemia.
Possible mechanisms: increased release of insulin. increased insulin sensitivity, masking of hypoglycemic symptoms, decreased hepatic gluconeogenesis, decreased glucose absorption
Drugs causing hypoglycemia during an overdose:
(1) aspirin (especially in children)
(3) acetaminophen (with hepatic necrosis)
Drugs that may induce hypoglycemia in patients:
(1) nonselective beta-blockers
(2) sulfamethoxyzole (similar to sulfonylurea)
(4) pentamidine (early after exposure, followed later by hyperglycemia)
(5) beta-2 agonists
(8) monoamine oxidase inhibitors
(9) tricyclic antidepressants
(10) angiotensin-converting enzyme (ACE) inhibitors
(11) alpha blocking agents
(12) clofibrate and other fibric acid derivatives
(14) lithium (in non-insulin dependent diabetics)
(21) fluoroquinolone antibiotics
The presence of two or more of these agents may cause hypoglycemia when a smaller number does not.
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Purpose: To identify drugs other than insulin or oral hypoglycemic agents that can cause hypoglycemia.
Specialty: Endocrinology, Clinical Laboratory
Objective: other testing, drug interactions, adverse effects
ICD-10: E16.0, E16.1, E16.2,